WebJul 1, 2008 · We previously showed that >90% of macrophages infiltrating the adipose tissue of obese animals and humans are arranged around dead adipocytes, forming characteristic crown-like structures (CLS). WebMacrophage infiltration induces chronic mild inflammation widely considered as a causative factor for insulin resistance and eventually diabetes. We previously showed that >90% of …
3D microscopy and deep learning reveal the …
WebApr 9, 2024 · The white adipose tissue stores energy as triglycerides while the brown adipose tissue helps to dissipate energy as heat. The endocannabinoid system regulates several functions of the adipose tissues to favor energy accumulation. ... a CB 1 receptor antagonist, for 4 weeks displayed lesser formation of crown-like structures around … WebDec 1, 2007 · ATMΦs in crown-like structures surrounding dead adipocytes expressed TNF-α and IL-6 proteins. Adipocyte number began to decline at week 12. At week 16, adipocyte death reached ∼80%, coincident with maximal expression of CD11c and inflammatory genes, loss (40%) of eAT mass, widespread collagen deposition, and … is spud webb still alive
Macrophage-inducible C-type lectin underlies obesity-induced adipose …
WebInterestingly, while crown-like structures and inflammatory cytokines were evident in adipose tissues of HFHS-fed mice but not in adipose tissues of LF-fed mice, a more robust increase in crown-like structures and inflammatory cytokines were observed in adipose tissues of VHF-fed mice compared to LF-fed as well as HFHS-fed mice (Figure 4F–I ... WebAlong with macrophages, CD8 + T cells participate in formation of crown-like structures (CLSs) surrounding dying/dead adipocytes in adipose tissue of mice . Increased infiltration as well as IL-12– and IL-18–mediated proliferation and activation may contribute to the increase and activation of CD8 + T cells in adipose tissue in obese mice ... WebInterleukin-22 (IL-22) is a cytokine with important functions in host defense and inflammatory responses and has recently been suggested to play a role in immune-inflammatory system in the context of obesity and its metabolic consequences. The specific cellular targets and mechanisms of IL-22-mediated obesity are largely unknown however. We here identified … is spud webb a hall of famer