Egr2 macrophage phagocytosis
WebAug 25, 2024 · Macrophages and other immune cells not only clear debris and combat microbes, they also coordinate cellular processes that initiate the subsequent phase of new tissue formation, which will occur 2–10 days after the injury. ... macrophages are a key cell type that not only perform clearing through phagocytosis, but also control such … WebMay 6, 2024 · Mechanistically, we show that EGR2 is driven by TGF-β and CSF-2 in a PPAR-γ-dependent manner to control alveolar macrophage differentiation. Functionally, …
Egr2 macrophage phagocytosis
Did you know?
WebJan 27, 2024 · Here, the regulation of macrophage-mediated tumor cell phagocytosis is first summarized, followed by an overview of strategies targeting macrophage phagocytosis for the development of antitumor therapies. WebMay 18, 2015 · The M2 macrophages have high phagocytosis capacity, producing extracellular matrix (ECM) components, angiogenic and chemotactic factors, and IL-10 [ 12, 13 ]. In addition to the pathogen defense, M2 macrophages clear apoptotic cells, can mitigate inflammatory response, and promote wound healing [ 8, 14 ].
WebJan 13, 2024 · A recent study suggested that EGR proteins (specifically EGR2) may also function in human monocyte-to-macrophage … WebOct 4, 2024 · Phagocytosis is a type of endocytosis, which is when cells ingest molecules via active transport as opposed to molecules passively diffusing through a cell membrane. Only certain small molecules can …
WebThis chapter presents a protocol for establishing primary mouse macrophage cultures, a method for polarizing macrophages to the M1 and M2 states, and a method for the in vitro study of macrophage phagocytosis of IgG-opsonized or IgM/complement component 3-opsonized erythrocytes. WebDec 23, 2015 · Egr2 labeled more M2 macrophages (~70%) than the canonical M2 macrophage marker Arginase-1, which labels 24% of M2 macrophages. Conversely, …
WebEGR2 (also termed Krox20) is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells. …
WebMar 18, 2024 · Here, we demonstrated macrophage phagocytosis as a key mechanism underlying the anticancer effect of therapeutic antibodies. The process is amendable by chemotherapeutic drugs such as paclitaxel, providing a potential combinatorial strategy to enhance the clinical benefit and/or overcome clinical resistance of anticancer antibodies. nuclear power plants in constructionWebNov 19, 2024 · Mechanistically, we show that EGR2 is driven by TGF-β and GM-CSF in a PPAR-γ–dependent manner to control alveolar macrophage differentiation. Functionally, EGR2 was dispensable for the regulation of lipids in the airways but crucial for the effective handling of the respiratory pathogen Streptococcus pneumoniae. nuclear power plants in japan metiWebDec 2, 2024 · Majority of these macrophages are derived from differentiated peripheral blood monocytes from the bone marrow and spleen. These macrophages orchestrate the myocardial repair response by secreting pro-/anti-inflammatory, pro-angiogenic, and pro-reparative factors, as well as removing dead cells through phagocytosis [ 4 – 9 ]. nine inch nails technoWebNov 19, 2024 · EGR2 is required for the phenotypic identity of alveolar macrophages. Previous work has suggested that EGR1 and EGR2 act in a redundant manner ( 20 ), … nine inch nails the big come downWebSep 3, 2024 · To determine if altered PGE 2 levels contributed to the impairment in phagocytosis, control macrophages were treated ex vivo with PGE 2 with or without the EP2 receptor inhibitor (AH6809). Stimulation with PGE 2 reduced monocyte/macrophage phagocytosis, but this was rescued in the monocyte/macrophages with blockage of the … nuclear power plants in greeceWebJul 24, 2024 · The transcription factors Egr2 and 3 are essential for controlling inflammatory autoimmune responses of memory phenotype (MP) CD4 T cells. However, the mechanism is still unclear. We have now … nuclear power plants in germanyWebNational Center for Biotechnology Information nuclear power plants in map