http://www.bjbalb.com/html/Antigen/GH0006.html Web18 de jun. de 2024 · 因此,hif-1α 与 pvhl 的结合介导了 hif-1α 的泛素化和蛋白酶体降解。 在缺氧期间,氧减少导致 PHD 蛋白对 HIF-1α 的脯氨酰羟基化作用减弱。 非羟基化的 HIF-1α 比羟基化的 HIF-1α 更稳定,从而导致蛋白质表达增加,该蛋白质随后可与 HIF-1β 相互作用并促进 HIF-1 靶基因的转录。
HIF-1α和SDF-1在糖尿病足大鼠创面中的表达及前列地尔 ...
Web1 材料与方法 1.1 细胞、试剂与仪器 胃癌BGC-823细胞、兔抗人HIF-1α多克隆抗体、兔抗人PKM2多克隆抗体、兔抗人GLUT-1多克隆抗体、羊抗兔IgG二抗、氯化钴(CoCl2)购自武汉博士德公司;GAPDH抗体、HIF-1α siRNA、Control siRNA购自美国Santa Cruz公司;蛋白提取试剂盒、蛋白检测试剂盒购自中国凯基生物公司;转染 ... Web3 de mar. de 2012 · While VHL also has HIF-1α-independent functions such as binding to and stabilizing p53 and acting as an adaptor for the phosphorylation of CARD9, 3 these proteins likely bind VHL differently than HIF-1α. In fact, previous work by Willam et al. has shown that polypeptides containing the HIF-1α oxygen-dependent degradation domains … short kit avion rc
缺氧与癌症:HIF-1α 在氧感应、代谢和肿瘤发生中的 ...
Web1 de jun. de 2024 · HIF-1 is associated with poor prognoses and therapeutic resistance in cancer patients. We previously developed a novel hypoxia-inducible factor (HIF)-1 inhibitor, IDF-11774, a clinical candidate ... Web15 de mar. de 2013 · Despite the controversies surrounding the involvement of HIF-1α and the isoform HIF-2α in regulating the oxygen stress response, the mechanisms underlying hypoxic inhibition of cell proliferation continue to be elucidated.Genetic studies of the mouse Hif1a gene indicate a role for HIF-1α in increasing the expression of p21 cip1 (7, 8), a … Web13 de fev. de 2014 · 结果显示hpc组hif-1α、vegf mrna及蛋白伤后1h提前表达并明显上调,在4h~7 d维持高表达,提示该条件下hpc可早期促进脑组织hif-1α、vegf上调并维持高 … short kitchen cabinets