Trifluoromethylthiolating
WebAug 25, 2014 · A new, electrophilic trifluoromethylthiosaccharin was developed and can be synthesized in two steps from saccharin within 30 minutes. A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N … WebJun 5, 2024 · a, Asymmetric trifluoromethylthiolation with electrophilic trifluoromethylthiolating reagents. b , Asymmetric trifluoromethylthiolation through enantioselective Doyle–Kirmse reaction. Full size ...
Trifluoromethylthiolating
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WebThe first C−SCF 3 /SeCF 3 cross-coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF 3 or Me 4 NSeCF 3, and organohalides as substrates are reported.The new methodology enables a one-stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio- and selenoethers with a broad substrate scope (>60 examples with up … WebShanghai Institute of Organic Chemistry, Chinese Academy of Sciences. 2013 年 8 月 - 2014 年 2 月7 个月. shanghai. worked as assistant professor in Prof. Guosheng Liu's lab focusing on the Cu-catalyzed C-F bond formation reactions and mentor graduate students.
WebSubstitution by the CF 3 S group allows for an increase in lipophilicity and electron-withdrawing properties along with an improvement in the bioavailability of medicinal … WebApr 30, 2024 · An efficient palladium-catalyzed trifluoromethylthiolation of chelation-assisted C–H bonds has been accomplished by employing a readily accessible trifluoromethylthiolating reagent. The reaction tolerates various directing groups and functional groups and allows the access to diverse trifluoromethylthiolated arenes in …
WebDec 1, 2024 · In 2014, we discovered that N-trifluoromethylthiosaccharin 5 was a highly reactive electrophilic trifluoromethylthiolating reagent that reacted with various electron-rich arenes when Me 3 SiCl or CF 3 SO 3 H was used a promoter (Scheme 1, Eq.4) [20].Later on, we reported that Friedel-Crafts-type of trifluoromethylthiolation of electron-rich arenes in … WebMay 20, 2014 · Furthermore, we also achieved the oxidative trifluoromethylthiolation reactions of aryl boronic acids and terminal alkynes to construct carbon-SCF3 bonds by using CF3SiMe3 and elemental sulfur as the nucleophilic trifluoromethylthiolating reagent.
WebThe invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.
WebOct 25, 2024 · The only successful benzylic C–H trifluoromethylthiolation strategy is copper-catalyzed oxidative trifluoromethylthiolation with AgSCF 3 but the reaction needs a large excess of simple toluene ... so keep your head up翻译WebJul 7, 2014 · A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from … soken chemical asiaWebA new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes.N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, … so keep your eyes on me now songWebAffiliation. A novel Cu-mediated trifluoromethylthiolation of diazo compounds has been developed that provides a convenient synthetic route for the efficient α-trifluoromethylthiolation of simple esters under mild reaction conditions. The reaction is typically carried out at room temperature, and water could be used to promote the reaction. soke ipad air caseWebAug 18, 2024 · The recent recognition of the novel application of a few traditional electrophilic trifluoromethylthiolating reagents as SCF 3 radical sources offers a remarkable new opportunity for the development of radical trifluoromethylthiolation reactions. Herein, the first trifluoromethylthio radical donating ability (Tt • DA) scale of electrophilic SCF 3 … sokenchem.comWebAug 23, 2024 · Herein, we report an alkali- and heat-free method for the trifluoromethylthiolation of aryl boronic acid substrates using a sulfonyl trifluoromethylthiolating reagent in the water phase. This method shows good tolerance towards various functional groups with satisfactory yields, thereby laying a firm … sluggish thyroid in womenWebA boron-catalyzed direct α-trifluoromethylthiolation of carboxylic acids was developed. Catalytically generated boron enediolates reacts with electrophilic SCF3 reagent, N-SCF3-phthalimide, to provide α-SCF3 carboxylic acids without the need of substrate pre-activation. The method is applicable to direct modification of bioactive carboxylic ... soke in the bath